Runners of predetermined ages participate in the annual edition. 200 volunteers are asked to undergo anthropometric measures (weight, height, body composition), cognitive (evaluation through questions or computer systems), conditional (strength, elasticity, sensitivity), functional (energy expenditure, precision) and organic (blood samples) before and just after the race. A group of runners, recruited in the first months of the year, is randomly divided into sub-groups subsequently assigned to different training modalities according to the scheme: Polarised training, Focused training and aerobic training, in order to define their potential and limits.
On the day of the event, normally in April, the sciencers think only about running 21 or 42 km and having fun, the researchers have the task of measuring, evaluating, collecting information. The data are statistically treated for scientific purposes in an anonymous form and can be used to produce publications in scientific journals or presented in written and oral form at national and international scientific congresses.